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By [http://ezinearticles.com/?expert=Zenith_Regan] Zenith Regan Hey Viagra users! Do you know how your magic pill works on you? Hmmmforgotten right! Or are you ignorant about its mechanism? Whatever, am sure about one thing you were startled after reading the title of this write-up! To understand Viagra mechanism we need to first understand how one gets a penis erection. Penile erection process is initiated with sexual excitement. The stimulation generates electrical impulses in the brain and sends it to the nerves going to the penile section. The nerve then releases nitric oxide to increase the production of cyclic GMP in muscle cells of corpus cavernosum simultaneously. Nitric oxide smoothes the muscles and increases the size of the blood vessels allowing high-speed blood flow to the penis. As a result the penis is engorged with blood making it firm and strong for penetrative sex. So what we understand from this is that the level of NO (Nitric oxide) is mainly responsible for giving a strong penile erection. Viagra does not have any direct relaxant effect on the penile section but it enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5). When sexual stimulation leads to the release of Nitric oxide, the inhibition of PDE5 by Viagra causes increased levels of cyclic guanosine monophosphate which gives muscle relaxation and blood inflow to the corpus cavernosum which ultimately helps in getting the required erections of the penis. Now, I am sure you will be able to relate the Nobel Prize winner Dr. Furchgott with Viagra and its functioning. Nitric oxide was initially known as Endothelial Derived Relaxing Factor (EDRF), ERDF was released, when patients took the nitrate-type blood pressure medicines popular in the 1970s and 1980s, and in turn it caused relaxation of the smooth muscles around the blood vessels and the arteries became larger, allowing better blood flow and a lower blood pressure. In 1986, Dr. Furchgott identified the EDRF as nitric oxide. This is where the Viagra makers got the idea of a magic pill for sex which revolutionized the whole idea of impotence. They noticed from the research that the nitrate drugs had certain side-effects on the blood vessels and the arteries; relaxing the smooth muscles around the blood vessels thereby increasing the blood flows in the human body. They related it to the erectile anatomy and discovered Sildenafil citrate, a chemical that inhibited PDE5 inhibitors which is responsible for the level of NO (nitric oxide) in the penile section. Sildenafil Citrate, under the brand name of Viagra, became the pioneer pill for the treatment of erectile dysfunction and received FDA approval on March 27, 1998, the rest is history! After all a better blood flow is the key factor behind a strong erection. So the master mind behind Viagra, in a way, remains Dr. Furchgott, the inventor of nitric oxide. Without the knowledge of the existence of nitric oxide, no one could think of inhibiting phosphodiesterase type 5 to maintain the level of NO to get penis erection. Lets toast for the good health of Dr. Furchgott and congratulate him on winning the Nobel Prize. Without his discoveries Viagra would not have been possible and millions of men with erectile dysfunction would have continued to live hopelessly and helplessly as ashamed impotents. Thanks Dr. Furchgott for everything you have given us through your discovery! The author is an amateur who addresses issues related to health & fitness, pharmaceuticals. If you wish to know more about the topic, please log onto [http://www.viagracare.com] http://www.viagracare.com Article Source: [http://ezinearticles.com/?expert=Zenith_Regan ] http://EzineArticles.com/?expert=Zenith_Regan [http://ezinearticles.com/?The-Discoverer-of-Nitric-Oxide-Wins-Nobel-Laureate,-Are-You-Aware-of-His-Relation-with-Viagra?&id=331488 ] http://EzineArticles.com/?The-Discoverer-of-Nitric-Oxide-Wins-Nobel-Laureate,-Are-You-Aware-of-His-Relation-with-Viagra?&id=331488 personal loan calculaters accountnow payday loan bad credit payday loan personal loans for less than perfect credit